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2020 Year In Review - Cholangiocarcinoma
2020 Year in Review - Cholangiocarcinoma
Modified FOLFOX versus Modified FOLFIRI in Patients with Locally Advanced or Metastatic Biliary Tract Cancer Refractory to First-Line Chemotherapy: A Phase 2 Study
2020 Year in Review - Cholangiocarcinoma
Results of a phase 2 study indicate that mFOLFIRI was not superior to mFOLFOX in the second-line treatment of patients with biliary tract cancer.
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Phase 3 ClarIDHy Study: Pharmacokinetics and Pharmacodynamics of Ivosidenib in Patients with Mutant IDH1 Advanced CCA
2020 Year in Review - Cholangiocarcinoma
Results of the PK/PD analysis of the ClarIDHy study showed that the study dose of the IDH1 inhibitor ivosidenib resulted in good exposure and inhibition of oncometabolite D-2-HG.
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In Patients with Advanced or Metastatic CCA and FGFR2 Fusions, Retrospective Analysis of Post–Second-Line Chemotherapy Outcomes
2020 Year in Review - Cholangiocarcinoma
Results of the retrospective analysis of phase 2 study of the FGFR1-3 selective tyrosine kinase inhibitor infigratinib indicate that efficacy outcomes in patients with CCA and FGFR2 fusions were better with third- or later-line infigratinib therapy compared with standard second-line chemotherapy.
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Adjuvant Concurrent Chemoradiotherapy in Patients with Extrahepatic CCA
2020 Year in Review - Cholangiocarcinoma
Retrospective analysis data indicate that adjuvant chemoradiotherapy was associated with improved survival compared with chemotherapy alone in patients with extrahepatic CCA.
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Combination Immunotherapy with Ipilimumab and Nivolumab Shows Activity in Patients with Advanced Biliary Tract Cancer
2020 Year in Review - Cholangiocarcinoma
Preliminary data suggest that dual blockade with ipilimumab and nivolumab might have antitumor activity in a subset of patients with microsatellite-stable biliary tract cancer.
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Nivolumab with Chemotherapy or Ipilimumab: First-Line Therapy for Patients with Advanced Unresectable Biliary Tract Cancer
2020 Year in Review - Cholangiocarcinoma
Phase 2 study results suggest that the addition of nivolumab and ipilimumab to chemotherapy as first-line therapy did not provide additional PFS benefit compared to standard-of-care chemotherapy in patients with advanced biliary tract cancer.
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Biomarker Analysis in a Phase 2 Study of Infigratinib (BGJ398) for CCA with FGFR2 Fusions
2020 Year in Review - Cholangiocarcinoma
Comprehensive genomic profiling of tumor tissue and cfDNA of patients enrolled in the phase 2 study of infigratinib underscored the heterogeneity of CCA and the potential clinical utility of cfDNA to identify FGFR2 fusions.
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A Meta-Analysis of Novel Therapeutics for CCA
2020 Year in Review - Cholangiocarcinoma
Meta-analysis identifies upregulation of several novel genes that have not been previously described, and suggests the potential role of ERBB2 and extracellular genes in the pathogenesis of CCA.
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Toripalimab, Lenvatinib, plus Chemotherapy a Promising Combination in Advanced Unresectable Intrahepatic CCA
2020 Year in Review - Cholangiocarcinoma
The multidrug combination of toripalimab, lenvatinib plus chemotherapy with gemcitabine and oxaliplatin showed promising efficacy and tolerability in patients with intrahepatic CCA.
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Primary versus Metastatic Intrahepatic CCA: A Comparative Comprehensive Genomic Profiling Study
2020 Year in Review - Cholangiocarcinoma
Comprehensive genomic profiling data indicate that genetic profile of primary intrahepatic CCA was significantly different from metastatic intrahepatic CCA, with different rates of potentially targetable genetic alterations.
Read More ›
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Home
Issues
Online First
2024
February 2024 - Vol 17 No 1
2023
December 2023 - Vol 16 No 6
October 2023 - Vol 16 No 5
August 2023 - Vol 16 No 4
June 2023 - Vol 16 No 3
April 2023 - Vol 16 No 2
February 2023 - Vol 16 No 1
Issue Archive
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ONS 2023 - Multiple Myeloma: Wrap-Up
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Best Practices in Breast Cancer Therapy | OFS
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