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Elacestrant Elicits Positive Outcomes in Patients with Metastatic Breast Cancer Who Have Progressed on Previous Endocrine Therapy
By
Patricia Stewart
Breast Cancer
TON - April 2022 Vol 15, No 2
The investigational oral selective estrogen receptor degrader (SERD) elacestrant (RAD1901) significantly reduced the risk for death or disease progression and improved progression-free survival (PFS) compared with standard-of-care (SOC) endocrine therapy in patients with estrogen receptor (ER)-positive,
HER2
-negative metastatic breast cancer who had progressed on prior endocrine and targeted therapies, according to results of the phase 3 EMERALD clinical trial.
Read More ›
Trastuzumab Deruxtecan Promising in Patients with HER2-Positive Breast Cancer and Stable Brain Metastases
SABCS
,
Breast Cancer
TON - February 2022 Vol 15, No 1
Second-line therapy with trastuzumab deruxtecan (Enhertu; T-DXd) extended progression-free survival (PFS) and improved objective response rate (ORR) versus trastuzumab emtansine (Kadcyla; T-DM1) in women with
HER2
-positive metastatic breast cancer, including those with stable brain metastasis at baseline, according to a subgroup analysis of a phase 3 clinical trial.
Read More ›
Sacituzumab Govitecan Moves to Second-Line Therapy for Metastatic Triple-Negative Breast Cancer: Applying the Lessons from Clinical Trials to Clinical Practice
Clinical Trials
,
Breast Cancer
February 2022 Clinical Trials to Clinical Practice
Each year, approximately 250,000 cases of breast cancer are diagnosed in the United States.
Read More ›
2021 Breast Cancer Year in Review Introduction
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
The COVID-19 pandemic continues to impact healthcare across the globe.
Read More ›
Highlights in Breast Cancer from ASCO 2021: An Interview with Virginia Kaklamani, MD
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
The phase 3 OlympiA trial showed olaparib had impressive results versus placebo, with improvement in disease-free survival with adjuvant olaparib in early-stage,
HER2
-negative breast cancer and
BRCA1/2
mutations. This highlights the need to test for
BRCA1/2
mutations to determine if patients qualify for olaparib.
Read More ›
Polyunsaturated Fatty Acids, Exercise, and Fatigue in Breast Cancer
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
A recent study found that omega-6 PUFA supplementation surprisingly reduced cancer-related fatigue in exhausted American breast cancer survivors when compared with omega-3 PUFA supplementation, and that omega-6 PUFA supplementation surprisingly lowered proinflammatory blood markers, completely against expectations.
Read More ›
A Web-Based Survey on Suggested Modifications in the Management of Patients with Breast Cancer During the COVID-19 Pandemic
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
Results of a recent web-based survey show that survey respondents are in favor of several changes in breast cancer treatment during COVID-19. These changes must be discussed on a local level, taking into consideration the infrastructure and resources available.
Read More ›
Real-World Patient-Reported Outcomes, Clinical Profile, and Treatment Patterns in a Subset of Patients with HR-Positive, HER2-Negative, Advanced Breast Cancer with Poor Prognostic Factors
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
In a real-world study, more than 60% of the HR-positive,
HER2
-negative advanced breast cancer samples had ≥1 disease-related poor prognostic factors. The need for more effective CDK4/6 inhibitor medication in these individuals is highlighted by their increased pain and impaired performance status.
Read More ›
Overall Survival in Patients with HR-Positive, HER2-Negative, Advanced or Metastatic Breast Cancer Treated with a CDK4/6 Inhibitor plus Fulvestrant: An FDA Pooled Analysis
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
Adding CDK4/6 inhibitors to fulvestrant resulted in an improvement in overall survival. These findings back up the current standard of care of CDK4/6 inhibitors plus fulvestrant for patients with HR-positive,
HER2
-negative, advanced breast cancer.
Read More ›
A Summary of PARP Inhibitors for the Treatment of Breast Cancer
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
PARP inhibitors offer the possibility of biomarker-targeted treatment for breast cancer. Therefore, it is necessary to quickly identify which patients may benefit from treatment and to guarantee that genetic testing is available.
Read More ›
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Home
Issues
2024
February 2024 - Vol 17 No 1
2023
December 2023 - Vol 16 No 6
October 2023 - Vol 16 No 5
August 2023 - Vol 16 No 4
June 2023 - Vol 16 No 3
April 2023 - Vol 16 No 2
February 2023 - Vol 16 No 1
Issue Archive
Special Issues
Supplements
Guide to New FDA Approvals
Categories
Conference Correspondent
ESMO 2023 - Small Cell Lung Cancer
ONS 2023 - Multiple Myeloma: Wrap-Up
Web Exclusives
OFS Summit
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Rapid Reactions
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CE
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