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2020 Year in Review - Neuroendocrine Tumors

Findings of a comparative real-world analysis of long-acting somatostatin analogs (SSAs) indicate that lanreotide was associated with lower injection burden, use of rescue medications, and cost.
Findings of a retrospective analysis suggest that patients with well-differentiated metastatic/unresectable grade 3 gastroenteropancreatic neuroendocrine tumors (GEP-NETs) may derive modest progression-free survival (PFS) benefit with somatostatin analog (SSA) monotherapy.
Results of the TELEPRO-II study showed that telotristat ethyl (TE) treatment resulted in significant, clinically relevant improvements across carcinoid syndrome (CS) symptoms in a real-world setting.
Safety analysis data of concomitant telotristat ethyl (TE) plus peptide receptor radionuclide therapy (PRRT) in patients with metastatic/nonresectable neuroendocrine tumors (NETs) and carcinoid syndrome diarrhea (CSD) indicate that the safety profile of combination treatment was consistent with individual TE and PRRT therapies.
Real-world clinical practice data indicate that telotristat ethyl (TE) use in patients with progressive neuroendocrine tumors (NETs) may provide clinical benefit in terms of improvements in carcinoid syndrome (CS) symptoms, functional status, and weight.
Post-hoc analytical data of the randomized phase 3 SANET-ep trial indicate that multitargeted tyrosine kinase inhibitor surufatinib therapy was associated with maintenance of health-related quality of life (HRQoL) in previously treated patients with progressive, well-differentiated, advanced extrapancreatic neuroendocrine tumors (NETs).
Results of a dose-escalation/expansion study in the US population among patients with extrapancreatic and pancreatic neuroendocrine tumors (NETs) indicate promising antitumor activity of the multitargeted tyrosine kinase inhibitor surufatinib, with a safety profile consistent with that previously described in the SANET-ep trial.
Subgroup analysis data of the randomized phase 3 SANET-ep trial indicate that the clinical benefits of the multitargeted tyrosine kinase inhibitor surufatinib therapy also extended to major subgroups by Ki67 and primary tumor origin in patients with advanced, well-differentiated extrapancreatic neuroendocrine tumors (NETs).
Findings of a retrospective analysis of real-world data indicate that retreatment with 2 extra cycles of peptide receptor radionuclide therapy (PRRT) with Lu-DOTATATE provided survival benefit in patients with disease progression after initial PRRT.
Findings of a retrospective analysis in patients with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) indicate that peptide receptor radionuclide therapy (PRRT) with Lu-DOTATATE may provide clinical benefit and does not significantly impair health-related quality of life (HRQoL).
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