Genetic Counseling

New Criteria for Inherited Prostate Cancer Genetic Testing

TON - March 2018, Vol 11, No 1 - Genetic Counseling

At least 3 clinical laboratories offer targeted panels for inherited prostate cancer. In addition, other laboratories analyze genes associated with prostate cancer risk, although they are not part of a targeted, inherited prostate cancer panel.

Is It Time to Reevaluate Universal Screening Strategies for Lynch Syndrome in Patients Newly Diagnosed with Colorectal Cancer?

Cristi Radford, MS, CGC, Nicole Centers, BSN, RN, OCN, CBCN, CN-BN

TON - September 2017, Vol 10, No 5 - Genetic Counseling

Lynch syndrome is a hereditary cancer syndrome that places individuals at an increased risk for colorectal, endometrial, stomach, ovarian, urothelial, and other cancers.

Survivorship Clinics—A Second Opportunity for Genetic Risk Stratification

Cristi Radford, MS, CGC, Nicole Centers, BSN, RN, OCN, CBCN, CN-BN

TON - July 2017, Vol 10, No 4 - Genetic Counseling

One of the challenges of improving cancer care is the integration of genetic risk assessment into survivorship care.

Therapeutic Implications—The Next Era of Genetic Diagnosis

Cristi Radford, MS, CGC

TON - May 2017, Vol 10, No 3 - Genetic Counseling

PARP inhibitors were the first class of drugs specifically developed to treat BRCA-related tumors by targeting the DNA repair pathway. Although they were developed more than a decade ago, the FDA only granted approval for their clinical use a few years ago.

New Data Suggest the Benefit of Multigene Panel Testing for Patients with Early-Onset Colorectal Cancer

Cristi Radford, MS, CGC

TON - March 2017, Vol 10, No 2 - Genetic Counseling

Screening of colorectal cancer (CRC) tumors for mismatch repair (MMR) deficiency has been shown to increase the identification of patients with Lynch syndrome.

Is It Time to Reconsider Testing Adolescents for Familial BRCA Mutations?

Courtney Lewis, MS, CGC , Cristi Radford, MS, CGC

TON - January 2017, Vol 10, No 1 - Genetic Counseling

Parents with inherited cancer mutations often wonder when to disclose results to their children and what affect it will have on them.

Risk and Management Updates for Inherited Colorectal Cancer

Courtney Lewis, MS, CGC , Cristi Radford, MS, CGC

TON - November 2016, Vol 9, No 6 - Genetic Counseling

Advances in technology and decreased testing costs have led to a rise in the number of genes associated with inherited cancer risk for which testing is clinically available.

Increased Risk for Serous/Serous-like Endometrial Cancer Found in BRCA1 Carriers

Cristi Radford, MS, CGC

TON - September 2016, Vol 9, No 5 - Genetic Counseling

BRCA1 and BRCA2 mutations have been shown to confer an increased risk for ovarian, fallopian tube, and primary perineal cancer. As a result, guidelines recommend bilateral salpingo-oophorectomy (BSO) upon completion of child bearing, and preferably between the ages of 35 and 40 years as a risk-reducing option. However, what has been less clear is the association of uterine cancer with BRCA. The data have been conflicting: some studies have suggested a slight increased risk, but others have not. Therefore, hysterectomy has not been included in national medical management guidelines.

“Newer” Ovarian Cancer Genes, Option of Risk-Reducing Salpingo-Oophorectomy

Cristi Radford, MS, CGC

TON July 2016 Vol 9 No 4 - Genetic Counseling

The ability to analyze multiple genes at the same time has led to the estimate that 20% to 25% of women with ovarian cancer have an inherited mutation in a cancer-predisposing gene.

The Evolving Phenotype of Li-Fraumeni Syndrome

Cristi Radford, MS, CGC

TON May 2016 Vol 9 No 3 - Genetic Counseling

In the past few years, some of the classic phenotypes and associated cancer risk estimates of inherited cancer syndromes have been questioned. This is due partly to increased access to genetic testing as well as to the availability of next-generation sequencing (NGS) panels for inherited cancer.

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