Preclinical studies suggested potential therapeutic synergy with the combination of atezolizumab and cobimetinib. To evaluate the combination, investigators conducted a 2-stage, phase 1b dose-escalation/cohort-expansion trial involving patients with several types of advanced solid tumors, including chemotherapy-refractory locally advanced or mCRC.
As the number of patients receiving immune checkpoint blockade grows, the combination of radiation and immunotherapy has become increasingly relevant, particularly in the palliative care setting, where radiation therapy is used to treat painful lesions or brain metastases.
Adding the investigational drug indoximod, an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor, to the checkpoint inhibitor pembrolizumab led to higher response rates in patients with advanced melanoma than what is reported with pembrolizumab monotherapy,
Despite remarkable advancements in the treatment of cancer through the use of targeted agents and immunotherapy, outcomes are still varied, and, for some patients, these regimens provide only a short-term answer.