Although primary amyloidosis is rare, oncology nurses have a broad range of responsibilities in managing patients who develop this disorder, researchers said.
“Oncology nurses educate patients about dietary changes that help prevent edema as well as safety measures that help prevent falls and fractures and additionally teach them which medications to avoid that may cause renal deterioration,” Noel B. Mendez, RN-BC, OCN, clinical nurse in the lymphoma and myeloma inpatient unit at The University of Texas M. D. Anderson Cancer Center in Houston, pointed out.
Oncology nurses also monitor cardiac, pulmonary, and renal function and manage chemotherapy-related side effects. Although primary amyloidosis is not a type of cancer, most patients are treated with chemotherapy, he said.
There are three types of amyloidosis: primary, secondary, and hereditary, Mendez noted. Primary amyloidosis is the most common form in the western hemisphere, but only approximately 3000 patients in the United States develop the disorder each year.
Primary amyloidosis, which may occur in patients with multiple myeloma, is actually a plasma disorder that develops within bone marrow, he said. Bone marrow produces proteins to create protective antibodies against infection. Normally, the protein antibodies are broken down and reabsorb in the body. However in primary amyloidosis, the protein antibodies are not broken down and instead accumulate in the bloodstream, migrating into multiple organs and leading to an amyloid buildup.
Diagnosis is based on clinical symptoms and tissue biopsy. Criteria have been established for determining amyloid- related major organ involvement, Mendez said.
The primary goals of treatment are elimination of amyloid production in the bone marrow and control of symptoms, which usually involves chemotherapy, Mendez said. Besides chemotherapy, symptom management may also include treatment of underlying illness, such as infection and inflammation.
The key responsibilities of the oncology nurse are:
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