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SABCS
Radius Investigational Drug Elacestrant (RAD1901) Continues to Show Promise in Advanced ER+ / HER2- Breast Cancer at the 2017 San Antonio Breast Cancer Symposium
SABCS
Conference Correspondent
Radius Health, Inc. (Nasdaq:RDUS) today provided an update on data from the Phase 1 005 clinical study of elacestrant (RAD1901), an oral selective estrogen receptor degrader (SERD), in patients with estrogen receptor positive (ER+) breast cancer. The data were presented at a Spotlight Presentation (Abstract 1410) during the 2017 San Antonio Breast Cancer Symposium (SABCS). Elacestrant recently received Fast Track designation from the U.S. Food and Drug Administration.
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Final Results of NeoMONARCH: A Phase 2 Neoadjuvant Study of Abemaciclib in Postmenopausal Women with HR-Positive, HER2-Negative Breast Cancer
SABCS
Conference Correspondent
The combination of abemaciclib plus anastrozole is superior to anastrozole alone in reducing Ki67 across a spectrum of subgroups of patients with hormone receptor (HR)-positive, HER2-negative breast cancer.
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Advantageous Polypharmacology of Abemaciclib Revealed by Omics Profiling of CDK4/6 Inhibitors
SABCS
Conference Correspondent
Abemaciclib, but not ribociclib or palbociclib, exhibits inhibition of CDK4/6 plus kinases other than CDK4/6, and induces cell death rather than cytostasis, which may be therapeutically advantageous in patients with hormone receptor‒positive breast cancer that is generally resistant to CDK4/6 inhibitors.
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ER-Positive Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors
SABCS
Conference Correspondent
Researchers have identified a CDK4/6 inhibitor–sensitive E2F4 gene expression signature in estrogen receptor (ER)-positive breast cancers resistant to aromatase inhibitors that can potentially identify patients with ER-positive breast cancer who are candidates for adjuvant therapy with CDK4/6 inhibitors in combination with antiestrogens.
Read More ›
Abemaciclib, Ribociclib, or Palbociclib for HR+ Metastatic Breast Cancer?
By
Matthew P. Goetz, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Matthew Goetz reviews what differentiates abemaciclib, the latest CDK4/6 inhibitor FDA-approved for HR+ metastatic breast cancer, from ribociclib and palbociclib.
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Hot Topics at SABCS 2017
By
Hope S. Rugo, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Hope Rugo provides an overview of some hot topics being covered at SABCS 2017 in the areas of hormone therapy, immunotherapy, neoadjuvant therapy, and more.
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HER2+ Breast Cancer and CDK4/6 Inhibitors
By
Hope S. Rugo, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Hope Rugo discusses studies that are aiming to evaluate the effect that CDK4/6 inhibitors have on patients with HER2+ breast cancer.
Read More ›
Disease Progression with a CDK4/6 Inhibitor plus an Aromatase Inhibitor
By
Hope S. Rugo, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Hope S. Rugo, MD, describes how she would treat a patient with HER-positive metastatic breast cancer that has progressed with a CDK4/CDK6 inhibitor plus an aromatase inhibitor.
Read More ›
What Differentiates Abemaciclib, Ribociclib, and Palbociclib?
By
Hope S. Rugo, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Hope Rugo addresses some of the main differences between the 3 CDK4/6 inhibitors that are FDA-approved in HR-positive metastatic breast cancer.
Read More ›
Why CDK4/6 Inhibitors Are Effective in HR-Positive Metastatic Breast Cancer
By
Hope S. Rugo, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Hope Rugo cites that CDK4/6 inhibitors play a critical role in estrogen signaling and can be very effective in treating metastatic breast cancer when used in combination with hormone therapy.
Read More ›
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Issues
2024
February 2024 - Vol 17 No 1
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December 2023 - Vol 16 No 6
October 2023 - Vol 16 No 5
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June 2023 - Vol 16 No 3
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February 2023 - Vol 16 No 1
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ESMO 2023 - Small Cell Lung Cancer
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