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CE
2021 Year in Review - HER2-Negative Breast Cancer
Trastuzumab Deruxtecan Granted Breakthrough Therapy Designation in United States for Patients with HER2-Positive Metastatic Breast Cancer Treated with ≥1 Previous Anti-HER2–Based Regimens
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
In October 2021, trastuzumab deruxtecan was granted Breakthrough Therapy Designation by the FDA in the United States for the treatment of adult patients with unresectable or metastatic
HER2
-positive breast cancer who have received ≥1 previous anti-
HER2
–based regimens.
Read More ›
SASCIA Phase 3 Trial Evaluating Sacituzumab Govitecan in Patients with Primary HER2-Negative Breast Cancer with High Relapse Risk
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
SASCIA was a phase 3 trial evaluating sacituzumab govitecan, an antibody–drug conjugate that received accelerated approval from the FDA in 2020 for the treatment of patients with metastatic TNBC who have received ≥2 previous therapies for metastatic disease.
Read More ›
Sacituzumab Govitecan for Metastatic Triple-Negative Breast Cancer: An Overview of Clinical Management and Potential Toxicities
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
Sacituzumab govitecan is an effective new medication for people with metastatic TNBC that is well-tolerated. The most prevalent side effects seen in individuals with metastatic TNBC using sacituzumab govitecan are similar to those seen with chemotherapy and can be managed with early, proactive intervention.
Read More ›
Emerging Immunotherapy Combination Strategies for Breast Cancer: Dual Immune Checkpoint Modulation, Antibody–Drug Conjugates, and Bispecific Antibodies
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
Along with surgery, radiation, chemotherapy, and targeted therapy, immunotherapy has emerged as the fifth pillar of cancer treatment and is revolutionizing cancer treatment across the board.
Read More ›
Checkpoint Inhibitor Therapy for Metastatic Triple-Negative Breast Cancer
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
Treatment with ICIs in metastatic TNBC has shown encouraging results. Immunotherapy has shifted the paradigm of cancer treatment and opened new research opportunities. TNBC is characterized by immunologic activation while being the most common subtype of breast cancer.
Read More ›
Patient-Reported Outcomes from a Phase 3 Trial in Premenopausal Patients with ER-Positive, HER2-Negative, Lymph Node–Positive Breast Cancer
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
Neoadjuvant chemotherapy is becoming more popular for patients with locally advanced breast cancer. Downstaging may result in a smaller surgical extent or a higher breast conservation rate, and a better cosmetic outcome. Chemotherapy, on the other hand, has both short- and long-term complications.
Read More ›
Updates on Endocrine Therapy for Metastatic Breast Cancer
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
Endocrine therapy used in combination with CDK4/6 inhibitors, in particular, have transformed the metastatic breast cancer landscape, promisingly improving progression-free survival and overall survival among patients with HR-positive,
HER2
-negative metastatic breast cancer.
Read More ›
Effectiveness of Alpelisib plus Fulvestrant Compared with Real-World Standard Treatment Among Patients with HR-Positive, HER2-Negative, PIK3CA Mutation–Positive Breast Cancer
Breast Cancer
2021 Year in Review - HER2-Negative Breast Cancer
The therapeutic advantage of alpelisib over fulvestrant in the treatment of patients with HR-positive,
HER2
-negative breast cancer and other malignancies is further enhanced by a matched/weighted analysis comparing BYLieve with the real-world scenario.
Read More ›
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ESMO 2023 - Small Cell Lung Cancer
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