Patients receiving the neurokinin 1 (NK1) antagonist aprepitant as part of a preparative regimen prior to stem-cell transplant had improved control of acute and delayed nausea and vomiting, and the drug did not interfere with antitumor efficacy, according to investigators from a prospective, randomized, double-blind, phase 3 trial.
Debate continues as to whether all patients with early human epidermal growth factor receptor type 2 (HER2)+ breast cancer need an anthracycline with trastuzumab. Updated data from the Breast Cancer International Research Group (BCIRG)-006 trial suggest that eliminating the anthracycline will have comparable efficacy and be less toxic.
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