TON - July 2018, Vol 11, No 3

Variants of Uncertain Significance—Frequently Asked Questions

Cristi Radford, MS, CGC, and Michele Gabree, MS, CGC, explain what variants of uncertain significance are, and address some of the questions that are frequently asked by providers.

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Nivolumab Shows Durable Activity in Subgroups of Patients with Metastatic CRC

The FDA granted accelerated approval to nivolumab based on a notable clinical benefit in a subset of patients who progressed after receiving the standard first-line chemotherapy with fluoropyrimidine, oxaliplatin, and irinotecan.

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Encourage Minority Patients with Ovarian Cancer to Participate in Clinical Trials

“Compared to those not enrolled in clinical trials, the evidence shows that the minority patients participating in clinical trials had increased overall survival,” said Khilen B. Patel, MD, at the 2018 Society of Gynecologic Oncology Annual Meeting on Women’s Cancer.

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Acquired HER2 Mutations in Metastatic Breast Cancer Confer Resistance to ER-Directed Therapy
A new study presented at the 2018 American Association for Cancer Research meeting suggests that HER2 mutations can be acquired during metastatic cancer and their development represents a previously unreported mechanism of resistance to treatment. Read More ›

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