Ovarian Cancer

Results of the phase 3, randomized ARIEL4 trial demonstrate that patients with BRCA-mutated advanced, relapsed ovarian cancer derive significant progression-free survival benefit from rucaparib therapy compared with standard-of-care chemotherapy, with the emergence of no new safety signals. Read More ›

Preliminary results of a phase 1 study showed favorable safety and tolerability of ribociclib, both concurrently with platinum and taxane chemotherapy and as maintenance therapy, with encouraging antitumor activity in patients with recurrent platinum-sensitive ovarian cancer Read More ›

Final analysis of the NOVA trial supports the long-term progression-free survival benefit and safe use of niraparib beyond first progression for maintenance treatment in patients with platinum-sensitive recurrent ovarian cancer. Read More ›

Results of the phase 2 APPROVE trial demonstrated significant prolongation of progression-free survival with the addition of apatinib to PLD in patients with platinum-resistant or refractory recurrent ovarian cancer, with an adverse event profile consistent with that previously described for apatinib and PLD. Read More ›

Results of a placebo-controlled, phase 2 study (MORAb-003-011/ENGOT-ov27) indicate that the addition of farletuzumab to platinum-based chemotherapy was not superior to placebo/chemotherapy in improving progression-free survival or other efficacy parameters in patients with platinum-sensitive recurrent ovarian cancer in first relapse who had low alemtuzumab CA-125 levels. Read More ›

Olaparib was more cost-effective, compared with niraparib, as maintenance therapy for patients with recurrent platinum-sensitive ovarian cancer, as determined by a model-based analysis. Read More ›

Primary results of a randomized phase 3 trial indicate that prolonged treatment with bevacizumab for up to 30 months does not provide survival benefit in patients with advanced ovarian cancer; therefore, bevacizumab treatment duration of 15 months remains the standard of care in this setting. Read More ›

Results of the NeoPembrOV phase 2 trial support the safe addition of pembrolizumab to neoadjuvant chemotherapy in patients deemed nonoptimally resectable. Although the addition of pembrolizumab resulted in an improved complete resection rate, it did not provide a progression-free survival benefit. Read More ›

Results of the phase 1b FORWARD II trial show that the MIRV/bevacizumab combination demonstrates promising antitumor activity with durable responses and favorable tolerability in high FRα recurrent ovarian cancer. Read More ›

Results of a dose-escalation phase 1 study indicated that AVB-500 is well-tolerated in combination with paclitaxel or pegylated liposomal doxorubicin, with higher antitumor activity seen in combination with paclitaxel, and no previous exposure to bevacizumab. Read More ›

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