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First-Line Treatment of Metastatic Non-Small-Cell Lung Cancer: Checkmate 9LA
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Web Exclusives
Keynote: How Has the Management of Young ER-Positive Breast Cancer Patients Changed Over the Years?
OFS Summit
Web Exclusives
Adjuvant treatment options for premenopausal women with hormone receptor–positive breast cancer now include endocrine therapy and ovarian function suppression (OFS) based on clinicopathologic characteristics that determine composite risk of recurrence.
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Adjuvant Hormonal Therapy for Premenopausal Breast Cancer: Considerations for Ovarian Function Suppression
OFS Summit
Web Exclusives
Understanding the role of the estrogen receptor (ER) in the pathogenesis of breast cancer has led to the development of treatment options that lead to reduced estrogen levels. In addition, the expression level of ER can serve as a prognostic indicator for disease recurrence and treatment response.
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Timing, Schedule, and Length of Gonadotropin-Releasing Hormone Agonist Therapy in Breast Cancer
OFS Summit
Web Exclusives
With the availability of approaches for preserving fertility and ovarian function, physicians should be prepared to discuss the impact of chemotherapy on fertility and ovarian function with patients newly diagnosed with breast cancer in order to personalize treatment plans based on patients’ goals. In the modern era, an increasing number of women are opting to delay pregnancy.
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Measuring Estradiol During Ovarian Function Suppression
OFS Summit
Web Exclusives
Measuring estradiol levels during ovarian function suppression (OFS) remains debatable. It can be argued that the assessment of estradiol levels is clinically irrelevant since general OFS can be achieved with the currently available approaches, and the outcomes of OFS trials are not based on estradiol levels. However, a variety of factors may lead to ovarian escape (OE).
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Rationale and Evidence for Ovarian Function Suppression as a Fertility Preservation Strategy: Beyond the POEMS Trial
OFS Summit
Web Exclusives
Despite the fact that 51% of patients with breast cancer have reported fertility concerns, evidence indicates that fertility preservation methods are underutilized.
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Rationale and Evidence for Ovarian Function Suppression as a Strategy for Ovarian Function Preservation: The POEMS Trial and Beyond
OFS Summit
Web Exclusives
Studies have demonstrated that at least half of patients undergoing treatment for breast cancer are concerned about potential infertility and demonstrate interest in becoming pregnant after the conclusion of their treatment. Even those not interested in pregnancy seek to avoid ovarian insufficiency and early menopause, which can negatively impact patients’ quality of life—an important treatment goal.
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Insights Into Physician Prescribing Decisions: Why Goserelin? Why Leuprolide?
OFS Summit
Web Exclusives
In the United States, 2 gonadotropin-releasing hormone (GnRH) agonists, goserelin and leuprolide, are widely available for ovarian function suppression (OFS) in patients with breast cancer. The ovarian-protective effects of GnRH agonists are mediated by downregulating GnRH receptors in the pituitary gland, which suppresses the release of luteinizing hormone and follicle-stimulating hormone.
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Formulary Access and the Key Drivers for Decision-making From Institution Representatives: Why Do We Select Goserelin? Why Did We Select Leuprolide? Why Did We Select Triptorelin?
OFS Summit
Web Exclusives
In Latin American countries, the onset of breast cancer is approximately 10 years earlier than in high-income countries. Moreover, the incidence rate of breast cancer in individuals aged <40 years is close to 11%, which is higher than the rates in developed regions such as the United States and the European Union. Additionally, most of these young women are diagnosed with advanced-stage disease.
Read More ›
Managing the Effects of Estrogen Deprivation
OFS Summit
Web Exclusives
A growing body of research has demonstrated that 5 to 10 years of adjuvant endocrine therapy (ET) plus ovarian function suppression (OFS) in patients with estrogen receptor (ER)-positive breast cancer reduces disease recurrence and mortality. However, despite this proven benefit, adverse events (AEs) associated with ET plus OFS may have a negative impact on patients’ quality of life.
Read More ›
Sequencing of Therapies in Premenopausal Metastatic Breast Cancer Patients
OFS Summit
Web Exclusives
In addition to the consideration of patient age, treatment selection for advanced breast cancer should include consideration of disease characteristics as outlined in evidence-based guidelines.
Read More ›
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Issues
2024
February 2024 - Vol 17 No 1
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December 2023 - Vol 16 No 6
October 2023 - Vol 16 No 5
August 2023 - Vol 16 No 4
June 2023 - Vol 16 No 3
April 2023 - Vol 16 No 2
February 2023 - Vol 16 No 1
Issue Archive
Special Issues
Supplements
ASK THE EXPERT:
First-Line Treatment of Metastatic Non-Small-Cell Lung Cancer: Checkmate 9LA
Guide to New FDA Approvals
Categories
Conference Correspondent
ESMO 2023 - Small Cell Lung Cancer
ONS 2023 - Multiple Myeloma: Wrap-Up
Web Exclusives
OFS Summit
Interview with the Innovators
Drug Updates
Media Library
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Rapid Reactions
Audiocasts
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CE
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